93 research outputs found

    Fast Reinforcement Learning with Large Action Sets Using Error-Correcting Output Codes for MDP Factorization

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    International audienceThe use of Reinforcement Learning in real-world scenarios is strongly limited by issues of scale. Most RL learning algorithms are unable to deal with problems composed of hundreds or sometimes even dozens of possible actions, and therefore cannot be applied to many real-world problems. We consider the RL problem in the supervised classification framework where the optimal policy is obtained through a multiclass classifier, the set of classes being the set of actions of the problem. We introduce error-correcting output codes (ECOCs) in this setting and propose two new methods for reducing complexity when using rollouts-based approaches. The first method consists in using an ECOC-based classifier as the multiclass classifier, reducing the learning complexity from O(A2) to O(Alog(A)) . We then propose a novel method that profits from the ECOC's coding dictionary to split the initial MDP into O(log(A)) separate two-action MDPs. This second method reduces learning complexity even further, from O(A2) to O(log(A)) , thus rendering problems with large action sets tractable. We finish by experimentally demonstrating the advantages of our approach on a set of benchmark problems, both in speed and performance

    Electrochemical integration of graphene with light absorbing copper-based thin films

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    We present an electrochemical route for the integration of graphene with light sensitive copper-based alloys used in optoelectronic applications. Graphene grown using chemical vapor deposition (CVD) transferred to glass is found to be a robust substrate on which photoconductive Cu_{x}S films of 1-2 um thickness can be deposited. The effect of growth parameters on the morphology and photoconductivity of Cu_{x}S films is presented. Current-voltage characterization and photoconductivity decay experiments are performed with graphene as one contact and silver epoxy as the other

    Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report

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    <p>Abstract</p> <p>Introduction</p> <p>Recent studies have reported a risk reduction in the progression of benign breast disease to breast carcinoma through COX-2 pathways.</p> <p>Case presentation</p> <p>We present a case of severe epithelial hyperplasia in a 47-year-old woman with increased breast density submitted to scintimammography by the proliferation-imaging tracer Technetium-99m-labelled pentavalent dimercaptosuccinic acid, before and after an oral ibuprofen treatment for 4 weeks. The radiotracer uptake after ibuprofen intake was significantly reduced, both visually and by semi-quantitative analysis, based on a calculation of lesion-to-background ratios.</p> <p>Conclusion</p> <p>In proliferating breast lesions, scintigraphically displayed reduction in Technetium-99m-labelled pentavalent dimercaptosuccinic acid uptake may indicate inhibition by ibuprofen in the pathway of malignant epithelial cell transformation.</p

    Status and perspectives of hospital mortality in a public urban Hellenic hospital, based on a five-year review

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    <p>Abstract</p> <p>Background</p> <p>Analysis of hospital mortality helps to assess the standards of health-care delivery.</p> <p>Methods</p> <p>This is a retrospective cohort study evaluating the causes of deaths which occurred during the years 1995–1999 in a single hospital. The causes of death were classified according to the International Statistical Classification of Diseases (ICD-10).</p> <p>Results</p> <p>Of the 149,896 patients who were discharged the 5836 (3.4%) died. Males constituted 55% and females 45%. The median age was 75.1 years (1 day – 100 years).</p> <p>The seven most common ICD-10 chapters IX, II, IV, XI, XX, X, XIV included 92% of the total 5836 deaths.</p> <p>The most common contributors of non-neoplasmatic causes of death were cerebrovascular diseases (I60–I69) at 15.8%, ischemic heart disease (I20–I25) at 10.3%, cardiac failure (I50.0–I50.9) at 7.9%, diseases of the digestive system (K00–K93) at 6.7%, diabetes mellitus (E10–E14) at 6.6%, external causes of morbidity and mortality (V01–Y98) at 6.2%, renal failure (N17–N19) at 4.5%, influenza and pneumonia (J10–J18) at 4.1% and certain infectious and parasitic diseases (A00–B99) at 3.2%, accounting for 65.3% of the total 5836 deaths.</p> <p>Neoplasms (C00–D48) caused 17.7% (n = 1027) of the total 5836 deaths, with leading forms being the malignant neoplasms of bronchus and lung (C34) at 3.5% and the malignant neoplasms of large intestine (C18–21.2) at 1.5%. The highest death rates occurred in the intensive care unit (23.3%), general medicine (10.7%), cardiology (6.5%) and nephrology (5.5%).</p> <p>Key problems related to certification of death were identified. Nearly half of the deaths (49.3%: n = 2879) occurred by the completion of the third day, which indicates the time limits for investigation and treatment. On the other hand, 6% (n = 356) died between the 29<sup>th </sup>and 262<sup>nd </sup>days after admission.</p> <p>Inadequacies of the emergency care service, infection control, medical oncology, rehabilitation, chronic and terminal care facilities, as well as lack of regional targets for reducing mortality related to diabetes, recruitment of organ donors, provision for the aging population and lack of prevention programs were substantiated.</p> <p>Conclusion</p> <p>Several important issues were raised. Disease specific characteristics, as well as functional and infrastructural inadequacies were identified and provided evidence for defining priorities and strategies for improving the standards of care. Effective transformation can promise better prospects.</p

    Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins

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    <p>Abstract</p> <p>Aim</p> <p>The aim of our study was to evaluate survival outcomes in malignant mixed Mullerian tumors (MMMT) of the uterus with respect to the role of cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components.</p> <p>Methods</p> <p>23 cases of uterine MMMT identified from the Saskatchewan Cancer Agency (1970-1999) were evaluated. Immunohistochemical expression of Bad, Mcl-1, bcl-x, bak, mdm2, bax, p16, p21, p53, p27, EMA, Bcl-2, Ki67 and PCNA was correlated with clinico-pathological data including survival outcomes.</p> <p>Results</p> <p>Histopathological examination confirmed malignant epithelial component with homologous (12 cases) and heterologous (11 cases) sarcomatous elements. P53 was strongly expressed (70-95%) in 15 cases and negative in 5 cases. The average survival in the p53+ve cases was 3.56 years as opposed to 8.94 years in p53-ve cases. Overexpression of p16 and Mcl-1 were observed in patients with longer survival outcomes (> 2 years). P16 and p21 were overexpressed in the carcinomatous and sarcomatous elements respectively. Cyclin-D1 was focally expressed only in the carcinomatous elements.</p> <p>Conclusions</p> <p>Our study supports that a) cell cycle and apoptotic regulatory protein dysregulation is an important pathway for tumorigenesis and b) p53 is an important immunoprognostic marker in MMMT of the uterus.</p

    The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells

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    INTRODUCTION: Medroxyprogesterone acetate (MPA), the major progestin used for oral contraception and hormone replacement therapy, has been implicated in increased breast cancer risk. Is this risk due to its progestational or androgenic properties? To address this, we assessed the transcriptional effects of MPA as compared with those of progesterone and dihydrotestosterone (DHT) in human breast cancer cells. METHOD: A new progesterone receptor-negative, androgen receptor-positive human breast cancer cell line, designated Y-AR, was engineered and characterized. Transcription assays using a synthetic promoter/reporter construct, as well as endogenous gene expression profiling comparing progesterone, MPA and DHT, were performed in cells either lacking or containing progesterone receptor and/or androgen receptor. RESULTS: In progesterone receptor-positive cells, MPA was found to be an effective progestin through both progesterone receptor isoforms in transient transcription assays. Interestingly, DHT signaled through progesterone receptor type B. Expression profiling of endogenous progesterone receptor-regulated genes comparing progesterone and MPA suggested that although MPA may be a somewhat more potent progestin than progesterone, it is qualitatively similar to progesterone. To address effects of MPA through androgen receptor, expression profiling was performed comparing progesterone, MPA and DHT using Y-AR cells. These studies showed extensive gene regulatory overlap between DHT and MPA through androgen receptor and none with progesterone. Interestingly, there was no difference between pharmacological MPA and physiological MPA, suggesting that high-dose therapeutic MPA may be superfluous. CONCLUSION: Our comparison of the gene regulatory profiles of MPA and progesterone suggests that, for physiologic hormone replacement therapy, the actions of MPA do not mimic those of endogenous progesterone alone. Clinically, the complex pharmacology of MPA not only influences its side-effect profile; but it is also possible that the increased breast cancer risk and/or the therapeutic efficacy of MPA in cancer treatment is in part mediated by androgen receptor

    Evaluation in artificial intelligence: From task-oriented to ability-oriented measurement

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    The final publication is available at Springer via http://dx.doi.org/ 10.1007/s10462-016-9505-7.The evaluation of artificial intelligence systems and components is crucial for the progress of the discipline. In this paper we describe and critically assess the different ways AI systems are evaluated, and the role of components and techniques in these systems. We first focus on the traditional task-oriented evaluation approach. We identify three kinds of evaluation: human discrimination, problem benchmarks and peer confrontation. We describe some of the limitations of the many evaluation schemes and competitions in these three categories, and follow the progression of some of these tests. We then focus on a less customary (and challenging) ability-oriented evaluation approach, where a system is characterised by its (cognitive) abilities, rather than by the tasks it is designed to solve. We discuss several possibilities: the adaptation of cognitive tests used for humans and animals, the development of tests derived from algorithmic information theory or more integrated approaches under the perspective of universal psychometrics. We analyse some evaluation tests from AI that are better positioned for an ability-oriented evaluation and discuss how their problems and limitations can possibly be addressed with some of the tools and ideas that appear within the paper. Finally, we enumerate a series of lessons learnt and generic guidelines to be used when an AI evaluation scheme is under consideration.I thank the organisers of the AEPIA Summer School On Artificial Intelligence, held in September 2014, for giving me the opportunity to give a lecture on 'AI Evaluation'. This paper was born out of and evolved through that lecture. The information about many benchmarks and competitions discussed in this paper have been contrasted with information from and discussions with many people: M. Bedia, A. Cangelosi, C. Dimitrakakis, I. GarcIa-Varea, Katja Hofmann, W. Langdon, E. Messina, S. Mueller, M. Siebers and C. Soares. Figure 4 is courtesy of F. Martinez-Plumed. Finally, I thank the anonymous reviewers, whose comments have helped to significantly improve the balance and coverage of the paper. This work has been partially supported by the EU (FEDER) and the Spanish MINECO under Grants TIN 2013-45732-C4-1-P, TIN 2015-69175-C4-1-R and by Generalitat Valenciana PROMETEOII2015/013.José Hernández-Orallo (2016). Evaluation in artificial intelligence: From task-oriented to ability-oriented measurement. Artificial Intelligence Review. 1-51. https://doi.org/10.1007/s10462-016-9505-7S151Abel D, Agarwal A, Diaz F, Krishnamurthy A, Schapire RE (2016) Exploratory gradient boosting for reinforcement learning in complex domains. arXiv preprint arXiv:1603.04119Adams S, Arel I, Bach J, Coop R, Furlan R, Goertzel B, Hall JS, Samsonovich A, Scheutz M, Schlesinger M, Shapiro SC, Sowa J (2012) Mapping the landscape of human-level artificial general intelligence. AI Mag 33(1):25–42Adams SS, Banavar G, Campbell M (2016) I-athlon: towards a multi-dimensional Turing test. AI Mag 37(1):78–84Alcalá J, Fernández A, Luengo J, Derrac J, García S, Sánchez L, Herrera F (2010) Keel data-mining software tool: data set repository, integration of algorithms and experimental analysis framework. J Mult Valued Logic Soft Comput 17:255–287Alexander JRM, Smales S (1997) Intelligence, learning and long-term memory. Personal Individ Differ 23(5):815–825Alpcan T, Everitt T, Hutter M (2014) Can we measure the difficulty of an optimization problem? In: IEEE information theory workshop (ITW)Alur R, Bodik R, Juniwal G, Martin MMK, Raghothaman M, Seshia SA, Singh R, Solar-Lezama A, Torlak E, Udupa A (2013) Syntax-guided synthesis. In: Formal methods in computer-aided design (FMCAD), 2013, IEEE, pp 1–17Alvarado N, Adams SS, Burbeck S, Latta C (2002) Beyond the Turing test: performance metrics for evaluating a computer simulation of the human mind. In: Proceedings of the 2nd international conference on development and learning, IEEE, pp 147–152Amigoni F, Bastianelli E, Berghofer J, Bonarini A, Fontana G, Hochgeschwender N, Iocchi L, Kraetzschmar G, Lima P, Matteucci M, Miraldo P, Nardi D, Schiaffonati V (2015) Competitions for benchmarking: task and functionality scoring complete performance assessment. IEEE Robot Autom Mag 22(3):53–61Anderson J, Lebiere C (2003) The Newell test for a theory of cognition. Behav Brain Sci 26(5):587–601Anderson J, Baltes J, Cheng CT (2011) Robotics competitions as benchmarks for AI research. Knowl Eng Rev 26(01):11–17Arel I, Rose DC, Karnowski TP (2010) Deep machine learning—a new frontier in artificial intelligence research. IEEE Comput Intell Mag 5(4):13–18Asada M, Hosoda K, Kuniyoshi Y, Ishiguro H, Inui T, Yoshikawa Y, Ogino M, Yoshida C (2009) Cognitive developmental robotics: a survey. IEEE Trans Auton Ment Dev 1(1):12–34Aziz H, Brill M, Fischer F, Harrenstein P, Lang J, Seedig HG (2015) Possible and necessary winners of partial tournaments. J Artif Intell Res 54:493–534Bache K, Lichman M (2013) UCI machine learning repository. http://archive.ics.uci.edu/mlBagnall AJ, Zatuchna ZV (2005) On the classification of maze problems. In: Bull L, Kovacs T (eds) Foundations of learning classifier system. Studies in fuzziness and soft computing, vol. 183, Springer, pp 305–316. http://rd.springer.com/chapter/10.1007/11319122_12Baldwin D, Yadav SB (1995) The process of research investigations in artificial intelligence - a unified view. IEEE Trans Syst Man Cybern 25(5):852–861Bellemare MG, Naddaf Y, Veness J, Bowling M (2013) The arcade learning environment: an evaluation platform for general agents. J Artif Intell Res 47:253–279Besold TR (2014) A note on chances and limitations of psychometric ai. In: KI 2014: advances in artificial intelligence. Springer, pp 49–54Biever C (2011) Ultimate IQ: one test to rule them all. New Sci 211(2829, 10 September 2011):42–45Borg M, Johansen SS, Thomsen DL, Kraus M (2012) Practical implementation of a graphics Turing test. In: Advances in visual computing. Springer, pp 305–313Boring EG (1923) Intelligence as the tests test it. New Repub 35–37Bostrom N (2014) Superintelligence: paths, dangers, strategies. Oxford University Press, OxfordBrazdil P, Carrier CG, Soares C, Vilalta R (2008) Metalearning: applications to data mining. Springer, New YorkBringsjord S (2011) Psychometric artificial intelligence. J Exp Theor Artif Intell 23(3):271–277Bringsjord S, Schimanski B (2003) What is artificial intelligence? Psychometric AI as an answer. In: International joint conference on artificial intelligence, pp 887–893Brundage M (2016) Modeling progress in ai. AAAI 2016 Workshop on AI, Ethics, and SocietyBuchanan BG (1988) Artificial intelligence as an experimental science. Springer, New YorkBuhrmester M, Kwang T, Gosling SD (2011) Amazon’s mechanical turk a new source of inexpensive, yet high-quality, data? Perspect Psychol Sci 6(1):3–5Bursztein E, Aigrain J, Moscicki A, Mitchell JC (2014) The end is nigh: generic solving of text-based captchas. In: Proceedings of the 8th USENIX conference on Offensive Technologies, USENIX Association, p 3Campbell M, Hoane AJ, Hsu F (2002) Deep Blue. Artif Intell 134(1–2):57–83Cangelosi A, Schlesinger M, Smith LB (2015) Developmental robotics: from babies to robots. MIT Press, CambridgeCaputo B, Müller H, Martinez-Gomez J, Villegas M, Acar B, Patricia N, Marvasti N, Üsküdarlı S, Paredes R, Cazorla M et al (2014) Imageclef 2014: overview and analysis of the results. In: Information access evaluation. Multilinguality, multimodality, and interaction, Springer, pp 192–211Carlson A, Betteridge J, Kisiel B, Settles B, Hruschka ER Jr, Mitchell TM (2010) Toward an architecture for never-ending language learning. In: AAAI, vol 5, p 3Carroll JB (1993) Human cognitive abilities: a survey of factor-analytic studies. Cambridge University Press, CambridgeCaruana R (1997) Multitask learning. Mach Learn 28(1):41–75Chaitin GJ (1982) Gödel’s theorem and information. Int J Theor Phys 21(12):941–954Chandrasekaran B (1990) What kind of information processing is intelligence? In: The foundation of artificial intelligence—a sourcebook. Cambridge University Press, pp 14–46Chater N (1999) The search for simplicity: a fundamental cognitive principle? Q J Exp Psychol Sect A 52(2):273–302Chater N, Vitányi P (2003) Simplicity: a unifying principle in cognitive science? Trends Cogn Sci 7(1):19–22Chu Z, Gianvecchio S, Wang H, Jajodia S (2010) Who is tweeting on twitter: human, bot, or cyborg? In: Proceedings of the 26th annual computer security applications conference, ACM, pp 21–30Cochran WG (2007) Sampling techniques. Wiley, New YorkCohen PR, Howe AE (1988) How evaluation guides AI research: the message still counts more than the medium. AI Mag 9(4):35Cohen Y (2013) Testing and cognitive enhancement. Technical repor, National Institute for Testing and Evaluation, Jerusalem, IsraelConrad JG, Zeleznikow J (2013) The significance of evaluation in AI and law: a case study re-examining ICAIL proceedings. In: Proceedings of the 14th international conference on artificial intelligence and law, ACM, pp 186–191Conrad JG, Zeleznikow J (2015) The role of evaluation in ai and law. In: Proceedings of the 15th international conference on artificial intelligence and law, pp 181–186Deary IJ, Der G, Ford G (2001) Reaction times and intelligence differences: a population-based cohort study. Intelligence 29(5):389–399Decker KS, Durfee EH, Lesser VR (1989) Evaluating research in cooperative distributed problem solving. Distrib Artif Intell 2:487–519Demšar J (2006) Statistical comparisons of classifiers over multiple data sets. J Mach Learn Res 7:1–30Detterman DK (2011) A challenge to Watson. Intelligence 39(2–3):77–78Dimitrakakis C (2016) Personal communicationDimitrakakis C, Li G, Tziortziotis N (2014) The reinforcement learning competition 2014. AI Mag 35(3):61–65Dowe DL (2013) Introduction to Ray Solomonoff 85th memorial conference. In: Dowe DL (ed) Algorithmic probability and friends. Bayesian prediction and artificial intelligence, lecture notes in computer science, vol 7070. Springer, Berlin, pp 1–36Dowe DL, Hajek AR (1997) A computational extension to the Turing Test. In: Proceedings of the 4th conference of the Australasian cognitive science society, University of Newcastle, NSW, AustraliaDowe DL, Hajek AR (1998) A non-behavioural, computational extension to the Turing test. In: International conference on computational intelligence and multimedia applications (ICCIMA’98), Gippsland, Australia, pp 101–106Dowe DL, Hernández-Orallo J (2012) IQ tests are not for machines, yet. Intelligence 40(2):77–81Dowe DL, Hernández-Orallo J (2014) How universal can an intelligence test be? Adapt Behav 22(1):51–69Drummond C (2009) Replicability is not reproducibility: nor is it good science. In: Proceedings of the evaluation methods for machine learning workshop at the 26th ICML, Montreal, CanadaDrummond C, Japkowicz N (2010) Warning: statistical benchmarking is addictive. Kicking the habit in machine learning. J Exp Theor Artif Intell 22(1):67–80Duan Y, Chen X, Houthooft R, Schulman J, Abbeel P (2016) Benchmarking deep reinforcement learning for continuous control. arXiv preprint arXiv:1604.06778Eden AH, Moor JH, Soraker JH, Steinhart E (2013) Singularity hypotheses: a scientific and philosophical assessment. Springer, New YorkEdmondson W (2012) The intelligence in ETI—what can we know? Acta Astronaut 78:37–42Elo AE (1978) The rating of chessplayers, past and present, vol 3. Batsford, LondonEmbretson SE, Reise SP (2000) Item response theory for psychologists. L. Erlbaum, HillsdaleEvans JM, Messina ER (2001) Performance metrics for intelligent systems. NIST Special Publication SP, pp 101–104Everitt T, Lattimore T, Hutter M (2014) Free lunch for optimisation under the universal distribution. In: 2014 IEEE Congress on evolutionary computation (CEC), IEEE, pp 167–174Falkenauer E (1998) On method overfitting. J Heuristics 4(3):281–287Feldman J (2003) Simplicity and complexity in human concept learning. Gen Psychol 38(1):9–15Ferrando PJ (2009) Difficulty, discrimination, and information indices in the linear factor analysis model for continuous item responses. Appl Psychol Meas 33(1):9–24Ferrando PJ (2012) Assessing the discriminating power of item and test scores in the linear factor-analysis model. Psicológica 33:111–139Ferri C, Hernández-Orallo J, Modroiu R (2009) An experimental comparison of performance measures for classification. Pattern Recogn Lett 30(1):27–38Ferrucci D, Brown E, Chu-Carroll J, Fan J, Gondek D, Kalyanpur AA, Lally A, Murdock J, Nyberg E, Prager J et al (2010) Building Watson: an overview of the DeepQA project. AI Mag 31(3):59–79Fogel DB (1991) The evolution of intelligent decision making in gaming. Cybern Syst 22(2):223–236Gaschnig J, Klahr P, Pople H, Shortliffe E, Terry A (1983) Evaluation of expert systems: issues and case studies. Build Exp Syst 1:241–278Geissman JR, Schultz RD (1988) Verification & validation. AI Exp 3(2):26–33Genesereth M, Love N, Pell B (2005) General game playing: overview of the AAAI competition. AI Mag 26(2):62Gerónimo D, López AM (2014) Datasets and benchmarking. In: Vision-based pedestrian protection systems for intelligent vehicles. Springer, pp 87–93Goertzel B, Pennachin C (eds) (2007) Artificial general intelligence. Springer, New YorkGoertzel B, Arel I, Scheutz M (2009) Toward a roadmap for human-level artificial general intelligence: embedding HLAI systems in broad, approachable, physical or virtual contexts. Artif Gen Intell Roadmap InitiatGoldreich O, Vadhan S (2007) Special issue on worst-case versus average-case complexity editors’ foreword. Comput complex 16(4):325–330Gordon BB (2007) Report on panel discussion on (re-)establishing or increasing collaborative links between artificial intelligence and intelligent systems. In: Messina ER, Madhavan R (eds) Proceedings of the 2007 workshop on performance metrics for intelligent systems, pp 302–303Gulwani S, Hernández-Orallo J, Kitzelmann E, Muggleton SH, Schmid U, Zorn B (2015) Inductive programming meets the real world. Commun ACM 58(11):90–99Hand DJ (2004) Measurement theory and practice. A Hodder Arnold Publication, LondonHernández-Orallo J (2000a) Beyond the Turing test. J Logic Lang Inf 9(4):447–466Hernández-Orallo J (2000b) On the computational measurement of intelligence factors. In: Meystel A (ed) Performance metrics for intelligent systems workshop. National Institute of Standards and Technology, Gaithersburg, pp 1–8Hernández-Orallo J (2000c) Thesis: computational measures of information gain and reinforcement in inference processes. AI Commun 13(1):49–50Hernández-Orallo J (2010) A (hopefully) non-biased universal environment class for measuring intelligence of biological and artificial systems. In: Artificial general intelligence, 3rd International Conference. Atlantis Press, Extended report at http://users.dsic.upv.es/proy/anynt/unbiased.pdf , pp 182–183Hernández-Orallo J (2014) On environment difficulty and discriminating power. Auton Agents Multi-Agent Syst. 29(3):402–454. doi: 10.1007/s10458-014-9257-1Hernández-Orallo J, Dowe DL (2010) Measuring universal intelligence: towards an anytime intelligence test. Artif Intell 174(18):1508–1539Hernández-Orallo J, Dowe DL (2013) On potential cognitive abilities in the machine kingdom. Minds Mach 23:179–210Hernández-Orallo J, Minaya-Collado N (1998) A formal definition of intelligence based on an intensional variant of Kolmogorov complexity. In: Proceedings of international symposium of engineering of intelligent systems (EIS’98), ICSC Press, pp 146–163Hernández-Orallo J, Dowe DL, España-Cubillo S, Hernández-Lloreda MV, Insa-Cabrera J (2011) On more realistic environment distributions for defining, evaluating and developing intelligence. In: Schmidhuber J, Thórisson K, Looks M (eds) Artificial general intelligence, LNAI, vol 6830. Springer, New York, pp 82–91Hernández-Orallo J, Flach P, Ferri C (2012a) A unified view of performance metrics: translating threshold choice into expected classification loss. J Mach Learn Res 13(1):2813–2869Hernández-Orallo J, Insa-Cabrera J, Dowe DL, Hibbard B (2012b) Turing Tests with Turing machines. In: Voronkov A (ed) Turing-100, EPiC Series, vol 10, pp 140–156Hernández-Orallo J, Dowe DL, Hernández-Lloreda MV (2014) Universal psychometrics: measuring cognitive abilities in the machine kingdom. Cogn Syst Res 27:50–74Hernández-Orallo J, Martínez-Plumed F, Schmid U, Siebers M, Dowe DL (2016) Computer models solving intelligence test problems: progress and implications. Artif Intell 230:74–107Herrmann E, Call J, Hernández-Lloreda MV, Hare B, Tomasello M (2007) Humans have evolved specialized skills of social cognition: the cultural intelligence hypothesis. Science 317(5843):1360–1366Hibbard B (2009) Bias and no free lunch in formal measures of intelligence. J Artif Gen Intell 1(1):54–61Hingston P (2010) A new design for a Turing Test for bots. In: 2010 IEEE symposium on computational intelligence and games (CIG), IEEE, pp 345–350Hingston P (2012) Believable bots: can computers play like people?. Springer, New YorkHo TK, Basu M (2002) Complexity measures of supervised classification problems. IEEE Trans Pattern Anal Mach Intell 24(3):289–300Hutter M (2007) Universal algorithmic intelligence: a mathematical top \rightarrow → down approach. In: Goertzel B, Pennachin C (eds) Artificial general intelligence, cognitive technologies. Springer, Berlin, pp 227–290Igel C, Toussaint M (2005) A no-free-lunch theorem for non-uniform distributions of target functions. J Math Model Algorithms 3(4):313–322Insa-Cabrera J (2016) Towards a universal test of social intelligence. Ph.D. thesis, Departament de Sistemes Informátics i Computació, UPVInsa-Cabrera J, Dowe DL, España-Cubillo S, Hernández-Lloreda MV, Hernández-Orallo J (2011a) Comparing humans and ai agents. In: Schmidhuber J, Thórisson K, Looks M (eds) Artificial general intelligence, LNAI, vol 6830. Springer, New York, pp 122–132Insa-Cabrera J, Dowe DL, Hernández-Orallo J (2011) Evaluating a reinforcement learning algorithm with a general intelligence test. In: Lozano JA, Gamez JM (eds) Current topics in artificial intelligence. CAEPIA 2011, LNAI series 7023. Springer, New YorkInsa-Cabrera J, Benacloch-Ayuso JL, Hernández-Orallo J (2012) On measuring social intelligence: experiments on competition and cooperation. In: Bach J, Goertzel B, Iklé M (eds) AGI, lecture notes in computer science, vol 7716. Springer, New York, pp 126–135Jacoff A, Messina E, Weiss BA, Tadokoro S, Nakagawa Y (2003) Test arenas and performance metrics for urban search and rescue robots. In: Proceedings of 2003 IEEE/RSJ international conference on intelligent robots and systems, 2003 (IROS 2003), IEEE, vol 4, pp 3396–3403Japkowicz N, Shah M (2011) Evaluating learning algorithms. Cambridge University Press, CambridgeJiang J (2008) A literature survey on domain adaptation of statistical classifiers. http://sifaka.cs.uiuc.edu/jiang4/domain_adaptation/surveyJohnson M, Hofmann K, Hutton T, Bignell D (2016) The Malmo platform for artificial intelligence experimentation. In: International joint conference on artificial intelligence (IJCAI)Keith TZ, Reynolds MR (2010) Cattell–Horn–Carroll abilities and cognitive tests: what we’ve learned from 20 years of research. Psychol Schools 47(7):635–650Ketter W, Symeonidis A (2012) Competitive benchmarking: lessons learned from the trading agent competition. AI Mag 33(2):103Khreich W, Granger E, Miri A, Sabourin R (2012) A survey of techniques for incremental learning of HMM parameters. Inf Sci 197:105–130Kim JH (2004) Soccer robotics, vol 11. Springer, New YorkKitano H, Asada M, Kuniyoshi Y, Noda I, Osawa E (1997) Robocup: the robot world cup initiative. In: Proceedings of the first international conference on autonomous agents, ACM, pp 340–347Kleiner K (2011) Who are you calling bird-brained? An attempt is being made to devise a universal intelligence test. Economist 398(8723, 5 March 2011):82Knuth DE (1973) Sorting and searching, volume 3 of the art of computer programming. Addison-Wesley, ReadingKoza JR (2010) Human-competitive results produced by genetic programming. Genet Program Evolvable Mach 11(3–4):251–284Krueger J, Osherson D (1980) On the psychology of structural simplicity. In: Jusczyk PW, Klein RM (eds) The nature of thought: essays in honor of D. O. Hebb. Psychology Press, London, pp 187–205Langford J (2005) Clever methods of overfitting. Machine Learning (Theory). http://hunch.netLangley P (1987) Research papers in machine learning. Mach Learn 2(3):195–198Langley P (2011) The changing science of machine learning. Mach Learn 82(3):275–279Langley P (2012) The cognitive systems paradigm. Adv Cogn Syst 1:3–13Lattimore T, Hutter M (2013) No free lunch versus Occam’s razor in supervised learning. Algorithmic Probability and Friends. Springer, Bayesian Prediction and Artificial Intelligence, pp 223–235Leeuwenberg ELJ, Van Der Helm PA (2012) Structural information theory: the simplicity of visual form. Cambridge University Press, CambridgeLegg S, Hutter M (2007a) Tests of machine intelligence. In: Lungarella M, Iida F, Bongard J, Pfeifer R (eds) 50 Years of Artificial Intelligence, Lecture Notes in Computer Science, vol 4850, Springer Berlin Heidelberg, pp 232–242. doi: 10.1007/978-3-540-77296-5_22Legg S, Hutter M (2007b) Universal intelligence: a definition of machine intelligence. Minds Mach 17(4):391–444Legg S, Veness J (2013) An approximation of the universal intelligence measure. Algorithmic Probability and Friends. Springer, Bayesian Prediction and Artificial Intelligence, pp 236–249Levesque HJ (2014) On our best behaviour. Artif Intell 212:27–35Levesque HJ, Davis E, Morgenstern L (2012) The winog

    Laparoscopic or open cholecystectomy in patients with sickle cell disease: which approach is superior?

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    To compare laparoscopic with open cholecystectomy in patients with sickle cell disease. Retrospective clinical study. University hospital, Greece. 41 patients (22 men and 19 women) with sickle cell disease had laparoscopic cholecystectomy between September 1991 and June 1998. Each patient was matched for age, sex, year of operation, and number of preoperative transfusions with control patients with sickle cell disease who had open cholecystectomy. Duration of operation, postoperative stay in hospital, incidence of complications, and conversion to open operation. The mean operation time was 81.4 min (range 55-125) for open cholecystectomy and 64.2 min (range 45-90) for laparoscopic cholecystectomy (p &lt; 0.01). Complications occurred in 5% (2/41) of the patients in the laparoscopic group and in 20% (8/41) of the patients in the open group (p = 0.04). The mean length of stay in hospital was 5.6 days (range 3-9) in the open group and 2.7 days (range 2-5) in the laparoscopic group (p &lt; 0.01). Conversion to open operation was necessary in 2 (5%) patients. Laparoscopic cholecystectomy resulted in a shorter hospital stay with fewer postoperative complications than open operation in patients with sickle cell disease and may be the procedure of choice in the treatment of cholelithiasis in such patients
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